Higher Circulating Resistin Levels Linked to Increased Sarcopenia Risk in Older Adults
Authors' conclusion
This study set out to establish a link between blood resistin levels and sarcopenia, suggesting that circulating resistin may serve as a potential biomarker reflecting poor muscle health in humans.
Study context
- Population
- Adults aged ≥65 years undergoing comprehensive geriatric evaluation in a geriatric clinical unit
- Participants
- 247 adults
- Comparison
- Sarcopenia, low muscle mass or weak muscle strength vs controls; highest vs lowest resistin quartile
- Outcome
- Sarcopenia (Asian-specific thresholds) in relation to serum resistin measured by ELISA
Methodological detailssingle geriatric clinical unit
- Single geriatric clinical unit
Main finding
As reported in the abstract
Circulating resistin concentration (adjusted for sex, age, fat mass, smoking, osteoarthritis, DM)
- Sarcopenia vs Controls: P = 0.002-.003
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Adverse muscle outcomes, highest vs lowest resistin quartileAt least 3 times higher odds | P = 0.007-.029 |
Resistin vs muscle measures
- Resistin inversely associated with skeletal muscle mass, gait speed and SPPB score; positively with 5 chair stands time (P = .019-.048)
Risk of sarcopenia, low muscle mass and weak muscle strength
- Higher resistin linked to increased risk (all P = .005)
Original publication
Higher Circulating Resistin Levels Linked to Increased Sarcopenia Risk in Older Adults. J Clin Endocrinol Metab. Published 25 December 2024. doi:10.
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