High triglyceride-glucose index predicts cardiovascular events in patients with coronary bifurcation lesions: a large-scale cohort study
Authors' conclusion
High TyG index was associated with CV events in patients with bifurcation lesions, suggesting the TyG index could help in risk stratification and prognosis in this population.
Study context
- Population
- Patients with angiography-proven coronary artery disease (CAD) and coronary bifurcation lesions, January 2017 to December 2018
- Participants
- 4,530 consecutive patients
- Exposure
- Triglyceride-glucose (TyG) index tertiles T2 and T3 vs T1
- Outcome
- CV events: CV death, nonfatal MI and nonfatal stroke
- Follow-up
- 3-year follow-up
Methodological detailsconsecutive patients, large-scale
- Consecutive patients
- Large-scale
Main finding
As reported in the abstract
CV events · median follow-up 3.1 years
Each group vs T1Hazard ratio (95% CI)
T2
1.68(1.06–2.65)
T3
2.10(1.28–3.47)
- Cardiovascular (CV) events occurred, all patients
- 141 (3.1%)
- Linear relationship between TyG index and events (restricted cubic spline (RCS), adjusted for age and male sex)
- non-linear P = 0.262
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CV events in diabetic patientsT3vs T1Adjusted for confounding factors | 2.68 (1.17–6.11) | |
| 0.10.31310Hazard ratio (log scale) |
3-year CV events across subgroups
- Consistent associations of the TyG index with CV events across various subgroups
Predictive performance
- Adding the TyG index to the original model significantly improved predictive performance
Original publication
High triglyceride-glucose index predicts cardiovascular events in patients with coronary bifurcation lesions: a large-scale cohort study. Cardiovasc Diabetol. Published 27 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →