High rate of abdominal aortic calcification in COPD patients and its relationship with musculoskeletal fragility
Authors' conclusion
COPD patients present a very high rate of AAC and its extended phenotype. Easily measured by conventional spine radiography, AAC severity in women with COPD is associated with low bone mass at the femoral neck, a surrogate marker for musculoskeletal fragility.
Study context
- Population
- Patients with COPD undergoing spirometry, laboratory work-up, bone mineral density (BMD) with body composition analysis and thoracolumbar spine radiography
- Participants
- 96 patients
- Exposure
- Men vs Women
- Menn = 44
- Womenn = 52
- Outcome
- Rate and severity of abdominal aortic calcification (Kauppila score) and its association with musculoskeletal outcomes
Main finding
As reported in the abstract
Abdominal aortic calcification
- Abdominal aortic calcification (AAC) ≥ 1
- Two-thirds of the participants
- Extended AAC (Kauppila score ≥ 5)
- 40.6%
Observational data: associations, not effects.
Further findings
Association with extended AAC (multivariate logistic regression)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Men: body fatTended to be associated with increased odds | 1.06 (0.99–1.13) | P = 0.099 | |
| 0.512Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Association with extended AAC (multivariate logistic regression)Women: femoral neck BMD (per 0.01 g/cm²) | 0.95 (0.92–0.99) | P = 0.018 | |
| 0.512Odds ratio (log scale) |
Densitometric osteoporosis and vertebral fractures (VFs) grades 2-3
- Densitometric osteoporosis
- almost 40%
- VFs grades 2-3
- 23%
Women: extended AAC (score ≥ 5) vs AAC score < 5
- Older age with extended AAC
- P = 0.044
- Lower femoral neck BMD with extended AAC
- P = 0.012
Original publication
High rate of abdominal aortic calcification in COPD patients and its relationship with musculoskeletal fragility. Osteoporos Int. Published 27 October 2022. doi:10.
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