Automated abdominal aortic calcification and major adverse cardiovascular events in people undergoing osteoporosis screening: the Manitoba Bone Mineral Density Registry
Authors' conclusion
In routine osteoporosis screening, individuals with moderate and high ML-AAC24 had substantially greater MACE rates compared to those with low ML-AAC24.
Study context
- Population
- Patients attending routine bone mineral density (BMD) testing with vertebral fracture assessment (VFA) (criteria based on age, BMD, height loss or glucocorticoid use), Manitoba BMD Registry, February 2010 to March 2017; mean age 75.5 yr, 94% women, without cardiovascular disease (CVD)
- Participants
- 10,250 patients
- Exposure
- Moderate and high vs low ML-AAC24
- Outcome
- MACE (from linked health records)
- Follow-up
- Mean 3.9 yr
Methodological detailsautomated machine learning assessment
- Automated machine learning assessment
Main finding
As reported in the abstract
MACE rate per 1000 person-years
Each group vs lowIncidence rate ratio (95% CI)
Moderate
1.9(1.6–2.2)
High
3.0(2.6–3.5)
- People with a major adverse cardiovascular event (MACE)
- 1265 (12.3%)
Observational data: associations, not effects.
Further findings
Per 1000 person-years
| Outcome | Low | Moderate | High | IRR (95% CI) | |
|---|---|---|---|---|---|
| MACE rate per 1000 person-years, subgroup <80 yr not on statinsModeratevs Low | 13.5 (95% CI 11.5–15.8) | 26.0 (95% CI 22.1–30.3) | 44.1 (95% CI 37.0–52.0) | 1.9 (1.5–2.4) | |
| MACE rate per 1000 person-years, subgroup <80 yr not on statinsHighvs Low | 3.3 (2.6–4.1) | ||||
| 0.20.5125Incidence rate ratio (log scale) |
Original publication
Automated abdominal aortic calcification and major adverse cardiovascular events in people undergoing osteoporosis screening: the Manitoba Bone Mineral Density Registry. J Bone Miner Res. Published 3 January 2025. doi:10.
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