High physical activity is associated with greater cortical bone size, better physical function, and with lower risk of incident fractures independently of clinical risk factors in older women from the SUPERB study
Authors' conclusion
In conclusion, high physical activity was associated with substantially better physical function and a lower risk of any fracture, MOF and hip fracture, independently of risk factors used in FRAX, FN BMD, and comorbidity.
Study context
- Population
- Women aged 75–80 yr from the population-based SUPERB study
- Participants
- 3,014 women
- Exposure
- Highest vs lowest quartile of Physical Activity Scale for the Elderly (PASE) score
- Outcome
- Incident X-ray verified fractures (any fracture, MOF, hip fracture)
- Follow-up
- 8 yr (median, range 0.20-9.9)
Methodological detailsPASE score quartiles, Cox regression adjusted for clinical risk factors (CRFs) in FRAX, femoral neck (FN) bone mineral density (BMD) and Charlson comorbidity index
- PASE score quartiles
- Cox regression adjusted for CRFs in FRAX, FN BMD and Charlson comorbidity index
Main finding
As reported in the abstract
Incident fractures · 8 yr (median, range 0.20-9.9)
Any fracture, Q4 vs Q1
30% lower risk
Major osteoporotic fracture (MOF), Q4 vs Q1
32% lower risk
Hip fracture, Q4 vs Q1
54% lower risk
Observational data: associations, not effects.
Further findings
| Outcome | Difference (%) | P value |
|---|---|---|
| Bone parameters, Q4 vs Q1 · baselineQ4 vs Q1 · cortical volumetric BMD | 1.56 | P = 0.007 |
| Bone parameters, Q4 vs Q1 · baselineQ4 vs Q1 · cortical area | 4.08 | P = 0.022 |
Fracture events (whole cohort) · 8 yr (median, range 0.20-9.9)
- Any fracture
- 1077 women
- MOF (spine, hip, forearm, humerus)
- 806 women
- Hip fracture
- 236 women
Physical performance, Q4 vs Q1 · baseline
- Timed up and go test
- 27% shorter
- One leg standing time
- 52% longer
Original publication
High physical activity is associated with greater cortical bone size, better physical function, and with lower risk of incident fractures independently of clinical risk factors in older women from the SUPERB study. J Bone Miner Res. Published 12 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →