High-normal levels of B-type natriuretic peptide are associated with chronic kidney disease progression independent of albuminuria in individuals with diabetes: an observational cohort study
Authors' conclusion
BNP is independently associated with kidney function decline, enabling graded risk stratification even within normal ranges. As a cardiac-derived marker of cardiorenal vulnerability, BNP complements urinary measures in identifying high-risk individuals with diabetes.
Study context
- Population
- Adults with diabetes
- Participants
- 636 adults
- Exposure
- BNP vs urinary markers for predicting chronic kidney disease (CKD) progression
- Outcome
- ≥30% estimated glomerular filtration rate (eGFR) decline
- Follow-up
- Median 5.4 years
Main finding
As reported in the abstract
- Participants reaching the endpoint
- 74
- BNP independently associated with CKD progression after adjustment for urinary albumin-to-creatinine ratio (UACR) and covariates
- p = 0.002
Observational data: associations, not effects.
Further findings
Baseline median BNP and UACR
- Median BNP
- 14.5 pg/mL
- Median UACR
- 21 mg/g
Original publication
High-normal levels of B-type natriuretic peptide are associated with chronic kidney disease progression independent of albuminuria in individuals with diabetes: an observational cohort study. Diabetes Res Clin Pract. Published 24 February 2026. doi:10.
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