High levels of serum C-peptide are associated with a decreased risk for incident renal progression in patients with type 2 diabetes: a retrospective cohort study
Authors' conclusion
Higher levels of 2hPCP, ΔCP and PCGR could protect T2DM patients from renal progression, especially in the aforementioned population with diabetes.
Study context
- Population
- Patients with T2D
- Participants
- 854 patients
- Exposure
- Higher vs lower serum C-peptide levels
- Outcome
- Renal composite endpoint
- Follow-up
- Median 5 years
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)
Higher 2hPCP
0.53(0.31–0.92)
Higher ΔCP
0.39(0.22–0.69)
Higher PCGR
0.44(0.24–0.82)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Annual eGFR declineHighest-level C-peptide vs Lowest-level C-peptide · smaller decline with highest level | P < 0.05 |
Kidney function progression in subgroups (male, age <65 years, disease course <10 years, HbA1c ≥7%, hypertension)
- 2hPCP <2.92 ng/mL, ΔCP <1.86 ng/mL and PCGR <1.11 significantly increased risk of progression
- adjusted HRs <0.50, p<0.05
Original publication
High levels of serum C-peptide are associated with a decreased risk for incident renal progression in patients with type 2 diabetes: a retrospective cohort study. BMJ Open Diabetes Res Care. Published 23 March 2023. doi:10.
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