High-Frequency 10-kHz Spinal Cord Stimulation Provides Long-term (24-Month) Improvements in Diabetes-Related Pain and Quality of Life for Patients with Painful Diabetic Neuropathy
Authors' conclusion
High-frequency 10-kHz SCS significantly decreased pain severity and provided additional clinically meaningful improvements in DQOL and overall functioning for patients with PDN. The robust and sustained benefits over 24 months, coupled with high participant satisfaction, highlight that 10-kHz SCS is an efficacious and comprehensive therapy for patients with PDN.
Study context
- Population
- Participants with refractory painful diabetic neuropathy (PDN)142 completed 24-month assessments
- Participants
- 216 participants
- Comparison
- 10-kHz spinal cord stimulation (SCS) + conventional medical management (CMM) vs CMM
Methodological detailscrossover allowed after six months
- Crossover allowed after six months
Primary result
As reported in the abstract
24 months
- Reduction in pain severity (Brief Pain Inventory for Diabetic Peripheral Neuropathy (BPI-DPN))
- 66.9% (P < .001)
- Reduction in pain interference with mood and daily activities (BPI-DPN)
- 65.8% (P < .001)
- Significant improvement in overall DQOL score
- P < .001
- Significant improvement in Global Assessment of Functioning (GAF) score
- P < .001
Further findings
Treatment satisfaction · 24 months
- Participants satisfied with treatment
- 91.5%
Original publication
High-Frequency 10-kHz Spinal Cord Stimulation Provides Long-term (24-Month) Improvements in Diabetes-Related Pain and Quality of Life for Patients with Painful Diabetic Neuropathy. J Diabetes Sci Technol. Published 6 October 2024. doi:10.
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