Hemoglobin glycation index and cardiovascular outcomes in patients with coronary intermediate lesions: insights from a large cohort study
Main finding · MACCEsResult — go to the resultHazard ratio 1.761 95% CI 1.233–2.515Authors' conclusion
HGI has a J-shaped association with MACCEs in patients with intermediate lesions. While a high HGI is a robust independent predictor of adverse events, a low HGI represents a non-significant trend.
Study context
- Population
- Patients with hemodynamically non-significant intermediate coronary lesions, enrolled during 2017
- Participants
- 5,932 patients
- Exposure
- Hemoglobin glycation index (HGI) tertiles
- Outcome
- Major adverse cardiovascular and cerebrovascular events (MACCEs)
- Follow-up
- median 4.91-year follow-up
Main finding
MACCEs · 5-year
Hazard ratio
1.761
95% CI 1.233–2.515
P = 0.002
High-HGIvs Medium-HGI
HR 1.761 (95% CI 1.233–2.515); P = 0.002
As reported in the abstract
- Optimal inflection point of HGI
- −0.24
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| MACCEs per 1-unit HGI increment above inflection point (−0.24) | 1.138 (1.073–1.207) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Major adverse cardiovascular and cerebrovascular events (MACCEs) overall · during follow-up
- MACCEs occurred
- 192 (3.2%)
Original publication
Hemoglobin glycation index and cardiovascular outcomes in patients with coronary intermediate lesions: insights from a large cohort study. Diabetes Res Clin Pract. Published 12 May 2026. doi:10.
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