Gut-Microbiota-Related Metabolite Phenylacetylglutamine and Risk of Incident Coronary Heart Disease Among Women
Authors' conclusion
Higher PAGln was associated with higher risk of CHD, particularly in women with dietary patterns of eating more animal foods and fewer plant-based foods. Adherence to plant-based diets might attenuate unfavorable associations between a novel microbial metabolite and CHD risk.
Study context
- Population
- Women from the Nurses' Health Study, followed 11 to 16 years; separate diet analysis in the Women's Lifestyle Validation Study (n = 725)
- Participants
- 1,520 women
- Comparison
- Higher vs lower plasma phenylacetylglutamine (PAGln)
- Casesn = 760
- Controlsn = 760reference
- Outcome
- Incident CHD by plasma PAGln levels
- Follow-up
- 11 to 16 years
Main finding
As reported in the abstract
Incident CHD by PAGln level
- Higher PAGln levels were related to a greater risk of coronary heart disease (CHD)
- P < .05 for dose-response relationship
Observational data: associations, not effects.
Further findings
PAGln and dietary intake (Women's Lifestyle Validation Study)
- Higher PAGln associated with greater red/processed meat intake and lower vegetable intake
- P < 0.05 for all
CHD per 1 SD higher PAGln, by plant-based diet index (PDI)
- Interaction between PAGln and PDI on CHD
- P for interaction = 0.008
- Relative risk per 1 SD PAGln, women with low PDI
- 1.22 (95% CI: 1.05, 1.41)
- No association among women with high PDI
Original publication
Gut-Microbiota-Related Metabolite Phenylacetylglutamine and Risk of Incident Coronary Heart Disease Among Women. J Clin Endocrinol Metab. Published 30 July 2024. doi:10.
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