Guideline on treatment intensification with injectable therapies beyond GLP-1 RA based therapies in type 2 diabetes
Methodological detailsGRADE framework, systematic search (updated November 2025), ≥ 80% consensus
- GRADE framework
- Systematic search (updated November 2025)
- ≥ 80% consensus
Recommendations
As issued by the authors
- conditional; very low certainty
Against switching to another GLP-1 RA
- conditional; low certainty
Switching to dual GIP/GLP-1 RA for glycemic and weight benefits
- conditional; very low to moderate certainty
Switching to fixed-ratio combination (FRC) when prioritizing glycemic improvement
- conditional; low certainty
Adding basal insulin with structured education
Choice among strategies should be individualized
Original publication
Guideline on treatment intensification with injectable therapies beyond GLP-1 RA based therapies in type 2 diabetes. Diabetes Res Clin Pract. Published 2 August 2026. doi:10.
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