Effect of a pharmacist-led mHealth app on adherence, quality of life, and glycaemic control in diabetes: A multicentre RCT
Primary result · Medication adherenceResult — go to the resultD (MMAS-8) 1.64Authors' conclusion
CareAide® significantly improves medication adherence and psychosocial quality of life.
Study context
- Population
- T2D cohort, three Malaysian hospitalsT2D cohort
- Participants
- 663 participants
- Comparison
- CareAide® pharmacist-driven mHealth app vs control
Methodological detailsopen-label, 6-month, structural equation modelling
- Open-label
- 6-month
- Structural equation modelling
Primary result
Medication adherence · 6 months
D (MMAS-8)
1.64
P < 0.001
By group
As reported in the abstract
Further findings
Early 3-month adherence as predictor of sustained 6-month adherence
- Strongest predictor of sustained 6-month adherence in both models (β std)
- 0.567 and 0.688; p < 0.001
AQoL-6D utility
- AQoL-6D utility improved significantly
- 0.669 vs 0.618
- Effect size d
- 0.353, p < 0.001
- Coping domain d
- 0.447
- Relationships domain d
- 0.254
Health-related quality of life (HRQoL) as mediator of adherence
- HRQoL did not mediate adherence; gains were a direct independent benefit
HbA1c
- Intervention effect, Proportion of Days Covered (PDC)-based structural equation modelling (SEM) model (not statistically significant)
- β = - 0.333, p = 0.065
- Group difference, baseline-adjusted ANCOVA
- β = - 0.41%, p = 0.002
- Complete-case comparison (non-significant)
- P = 0.153
- Glycaemic findings warrant cautious interpretation
cIPMA
- cIPMA identified the intervention as the primary optimisation target
Original publication
Effect of a pharmacist-led mHealth app on adherence, quality of life, and glycaemic control in diabetes: A multicentre RCT. Diabetes Res Clin Pract. Published 2 August 2026. doi:10.
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