Growth Without Growth Hormone in Sellar Germ Cell Tumors: Clinical Characteristics and Predictive Factors
Authors' conclusion
GWGH occurs in 11.5% of children with sellar GCTs and GHD and is associated with hypothalamic involvement, obesity, and hyperinsulinemia. Elevated fasting insulin may partly explain GWGH, but prospective studies are needed to clarify the underlying mechanisms.
Study context
- Population
- Children with sellar germ cell tumors (GCTs) and growth hormone deficiency (GHD), with hypogonadotropic hypogonadism or prepubertal status, July 2021–December 2024
- Participants
- 130 children
- Comparison
- Growth without growth hormone (GWGH) vs non-GWGH
- GWGHn = 15
- Outcome
- Clinical features and predictors of GWGH
Methodological detailssingle-centre, 1:2 age- and sex-matched controls
- Single-centre
- 1:2 age- and sex-matched controls
Main finding
As reported in the abstract
GWGH prevalence
15
11.5%
Observational data: associations, not effects.
Further findings
Fasting insulin · higher with GWGH
P < 0.001
Pituitary dysfunction and hormone replacement therapy
- Did not differ significantly between groups
Original publication
Growth Without Growth Hormone in Sellar Germ Cell Tumors: Clinical Characteristics and Predictive Factors. Endocr Pract. Published 17 December 2025. doi:10.
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