Growth hormone increase by luteinizing hormone-releasing hormone reflects gonadotroph-related characteristics in acromegaly
Authors' conclusion
The increased GH response to LHRH is associated with the gonadotroph-related characteristics. This response may reflect the biological characteristics of somatotroph tumors.
Study context
- Population
- Patients with acromegaly
- Participants
- 33 vs 81
- Comparison
- LHRH responders vs LHRH nonresponders
- LHRH respondersn = 33
- LHRH nonrespondersn = 81reference
- Outcome
- Clinical characteristics, especially gonadotroph-related characteristics
Main finding
As reported in the abstract
Gonadotroph-related characteristics
- SF-1, gonadotropin-releasing hormone receptor (GnRHR) and LH expression more frequent in LHRH responders
- Tumours with SF-1 expression: greater growth hormone (GH) increase after LHRH loading and higher proportion of GnRHR and gonadotropin expression than tumours without (P < 0.01)
- No differences in age, sex or basal serum GH, IGF-1 and gonadotropin between groups
- LHRH responders vs LHRH nonresponders: P < 0.05
Further findings
| Outcome | P value |
|---|---|
| Response to somatostatin analogues | P < 0.05 |
| T2 MRI hypointensity and densely granulated type | P < 0.05 |
- Response to somatostatin analogues: greater GH decrease in octreotide test and greater IGF-1 decrease after first-generation SRL in LHRH responders
- T2 MRI hypointensity and densely granulated type: higher proportion of T2-hypointense and densely granulated tumours in LHRH responders
Somatostatin receptor 2 and 5 expression
- No difference between groups in somatostatin receptor 2 or 5 expression
Original publication
Growth hormone increase by luteinizing hormone-releasing hormone reflects gonadotroph-related characteristics in acromegaly. Pituitary. Published 19 June 2024. doi:10.
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