Grandmaternal perinatal serum polychlorinated biphenyls and prevalence of obesity in adult daughters and granddaughters
Authors' conclusion
Grandmothers' perinatal serum levels of mixtures of PCBs may have triggered a multigenerational cycle of obesity in daughters and granddaughters. Resultant obesity among women of reproductive age could further perpetuate obesity in subsequent generations.
Study context
- Population
- Grandmother (F0)–daughter (F1)–granddaughter (F2) triads, Child Health and Development Studies; obesity in F1 at age 30 years and F2 at age 26 years
- Participants
- 258 triads
- Exposure
- Third vs first tertile of grandmaternal perinatal serum polychlorinated biphenyl (PCB) ratio
- Outcome
- Obesity in daughters (F1) and granddaughters (F2)
- Follow-up
- F1 age 30 years; F2 age 26 years
Methodological detailslogistic models accounting for family clustering
- Logistic models accounting for family clustering
Main finding
As reported in the abstract
Obesity
Each group vs first tertileEstimate (95% CI)
Third tertile
OR (F1 obesity) 1.73(1.06–2.82)
Third tertile
OR (F2 obesity) 1.96(1.12–3.42)
Observational data: associations, not effects.
Further findings
F2 obesity by F0 BMI
- Association with F2 obesity differed by F0 BMI
- P for interaction = 0.08
F1 obesity and F2 obesity
- F1 obesity associated with F2 obesity, OR
- 4.12 (95% CI 1.95-8.72)
Original publication
Grandmaternal perinatal serum polychlorinated biphenyls and prevalence of obesity in adult daughters and granddaughters. Obesity (Silver Spring). Published 24 April 2025. doi:10.
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