Glycemic status and its association with retinal age gap: Insights from the UK biobank study
Authors' conclusion
Dysglycemia was significantly associated with accelerated ageing indexed by retinal age gaps, highlighting the importance of maintaining glycemic status.
Study context
- Population
- UK Biobank participants with available glycemic status and qualified retinal imaging data
- Participants
- 28,919 participants
- Exposure
- Prediabetes and T2D vs normoglycemia
- Outcome
- Retinal age gap (retina-predicted age minus chronological age)
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
Retinal age gap
Regression coefficient [β]
0.25
95% CI 0.11–0.40P = 0.001
Prediabetes
β
1.06
95% CI 0.83–1.29P < 0.001
T2D
Observational data: associations, not effects.
Further findings
- Increase of HbA1c independently associated with higher retinal age gaps among all subjects or subjects without T2D
- Significant positive associations across increasing HbA1c and glucose groups vs normal level group
- Findings remained significant after excluding diabetic retinopathy
Original publication
Glycemic status and its association with retinal age gap: Insights from the UK biobank study. Diabetes Res Clin Pract. Published 6 July 2023. doi:10.
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