Glucose absorption in the duodenum is modulated by an estrogen receptor α-dependent regulation of glucose transporter functional expression
Authors' conclusion
Our findings suggest that, at least in premenopausal women and female mice, glucose absorption is in part regulated by estrogen via an ERα-dependent modulation of the functional expression of SGLT1 and GLUT2 in the duodenum.
Study context
- Population
- Women aged 20–30 years, ovariectomized mice and human intestinal epithelium cell line SCBN
- Comparison
- OVX mice vs controls; estrogen in SCBN cells; premenstrual vs preovulatory phase in women
- Outcome
- Estrogen and duodenal glucose absorption
Methodological detailsovariectomized mouse model, human cell line SCBN, human OGTT
- Ovariectomized mouse model
- Human cell line SCBN
- Human OGTT
Main finding
As reported in the abstract
- Women aged 20-30 years: correlation between estrogen and blood glucose; lower glucose tolerance in premenstrual vs preovulatory phase
- OVX mice vs controls: increased body weight and abdominal fat, decreased serum estradiol
- OVX mice vs controls: reduced duodenal ERα and ERβ expression, SGLT1 and GLUT2 expression, and glucose absorption
- SCBN cells: estrogen upregulated SGLT1 and GLUT2; silencing ERα, but not ERβ, reversed this
- Estrogen modulates protein kinase C (PKC) signaling downstream
Original publication
Glucose absorption in the duodenum is modulated by an estrogen receptor α-dependent regulation of glucose transporter functional expression. BMJ Open Diabetes Res Care. Published 27 July 2025. doi:10.
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