Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth
Authors' conclusion
In children with T1D-CD, worse glucometabolic control is associated with an increase in fold anti-TTG IgA and with worse Marsh grade. A slightly higher anti-TTG IgA cutoff may be necessary for sparing biopsy compared to children in the general population. Higher prevalence of autoimmune comorbidities in CD_FIRST suggests that screening for T1D in the CD population should be mandatory.
Study context
- Population
- Children and adolescents with T1D onset 2010–2019 (among 6933 individuals), with celiac disease (CD) at time of CD diagnosis556 T1D and CD (T1D-CD)
- Exposure
- T1D with CD vs T1D without CD
- T1D without CDn = 141reference
- Outcome
- Correlation of anti-TTG IgA titer, HbA1c when CD occurs (HbA1cCD) and Marsh grade
- Follow-up
- At CD diagnosis
Main finding
As reported in the abstract
HbA1cCD vs fold-anti-TTG IgA
HbA1cCD associated with increased fold-anti-TTG IgA (Spearman r)
0.14
P = .0047
Observational data: associations, not effects.
Secondary outcomes
| Outcome | χ2 | P value |
|---|---|---|
| Autoimmune comorbiditiesT1D-CD vs T1D without CD · more comorbidities in T1D-CD | 25.4 | P < 0.001 |
| Autoimmune comorbiditiesCD_FIRST vs T1D without CD · particularly CD_FIRST | P < 0.001 |
Optimal anti-TTG IgA cutoff for sparing biopsy
- Optimal anti-TTG IgA cutoff
- 11 upper limit of normal (ULN)
Original publication
Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth. J Clin Endocrinol Metab. Published 4 November 2025. doi:10.
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