Genetic Links Between Metabolic Syndrome and Osteoarthritis: Insights From Cross-Trait Analysis
Authors' conclusion
Our results illustrate a common genetic architecture, pleiotropic loci, as well as causality between MetS and OA, potentially enhancing our knowledge of high comorbidity and genetic processes that overlap between the 2 disorders.
Study context
- Population
- GWAS summary statistics from the UK Biobank and MAGIC for metabolic syndrome (MetS) and osteoarthritis (OA)
- Outcome
- Genetic connection between MetS and OA
Methodological detailsglobal genetic correlation analyses, genome-wide cross-trait meta-analyses, bidirectional two-sample Mendelian randomization
- Global genetic correlation analyses
- Genome-wide cross-trait meta-analyses
- Bidirectional two-sample Mendelian randomization
Pooled result
As reported in the abstract
Genetic correlation between MetS and OA (rg)
0.393
P = 1.52 × 10-18
Genetic correlation of 4 MetS components (waist circumference, triglycerides, hypertension, HDL-C) with OA, rg range
−0.229 to 0.490
Variants jointly associated with MetS and OA (Multi-Trait Analysis of GWAS (MTAG))
32
Genes shared between MetS and OA (co-localization)
12
Original publication
Genetic Links Between Metabolic Syndrome and Osteoarthritis: Insights From Cross-Trait Analysis. J Clin Endocrinol Metab. Published 14 March 2024. doi:10.
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