From Lobectomy to Completion Thyroidectomy: A Cohort Study and Systematic Review
Authors' conclusion
Completion thyroidectomy is performed in a significant minority of patients following initial lobectomy, most often due to adverse pathological features identified postoperatively.
Study context
- Population
- Patients who underwent completion thyroidectomy (CT) for thyroid cancer, 2017–2022 (institutional cohort); studies of patients initially undergoing lobectomy (systematic review)institutional cohort
- Participants
- 54 patients
- Outcome
- Rates and indications for completion thyroidectomy following initial lobectomy
Methodological detailssingle-institution cohort, PRISMA
- Single-institution cohort
- PRISMA
Pooled result
As reported in the abstract
CT rate following initial lobectomy
Institutional cohort: underwent CT following initial lobectomy
37%
Systematic review (30 studies, 23,899 patients): pooled weighted mean CT rate
19.2%
range: 4.9%–94.6%
Further pooled results
| Outcome | Tumour ≥1 cm or 1-4 cm | Size not clearly defined | P value |
|---|---|---|---|
| Mean CT rate by tumour size definition (subgroup analysis) | 45% | 16.1% | P < 0.001 |
| Studies | 14 | 16 |
Time between initial and completion surgeries (institutional cohort)
- Average interval
- 3.75 ± 3.8 months
Leading indications for CT (reported in 11 articles, 36.7%)
- Aggressive histologic variants
- 158, 25.4%
- Lymph node metastasis
- 143, 23%
- ETE
- 109, 17.5%
Original publication
From Lobectomy to Completion Thyroidectomy: A Cohort Study and Systematic Review. Clin Endocrinol (Oxf). Published 22 March 2026. doi:10.
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