Frequency of Rebound Hyperglycemia in Adults with Type 1 Diabetes Treated with Different Insulin Delivery Modalities
Authors' conclusion
Groups with insulin suspension features experienced the highest frequency of RH; however, AID users tended to experience shorter and less severe RH events.
Study context
- Population
- Adults with T1D using CGM attending the outpatient clinic at Steno Diabetes Center Copenhagen
- Exposure
- MDI vs unintegrated insulin pumps vs SAP vs automated insulin delivery (AID)
- Outcome
- Frequency of RH (≥1 SG >10.0 mmol/L starting within 2 h of an antecedent SG <3.9 mmol/L)
Methodological detailsreal-world, single-centre
- Real-world
- Single-centre
Main finding
As reported in the abstract
Incidence of RH
| Group | Value | Hypoglycemic events leading to RH |
|---|---|---|
| SAP | 2.06 ± 1.65 events per week | 41.3 ± 22.8% |
| AID | 2.08 ± 1.49 events per week | 39.6 ± 20.1% |
Value
SAP2.06 ± 1.65 events per week
AID2.08 ± 1.49 events per week
Hypoglycemic events leading to RH
SAP41.3 ± 22.8%
AID39.6 ± 20.1%
Observational data: associations, not effects.
Further findings
| Outcome | MDI | AID | P value |
|---|---|---|---|
| Duration of RH eventsAID vs MDI · shorter with AID | 185 ± 135 min | 122 ± 72 min | P < 0.0001 |
Severity of RH (AUC)
- Severity of RH inversely associated with more advanced technology
- P < 0.001
- Severity of RH inversely associated with TIR
- P < 0.001
Original publication
Frequency of Rebound Hyperglycemia in Adults with Type 1 Diabetes Treated with Different Insulin Delivery Modalities. Diabetes Technol Ther. Published 7 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →