Fracture risk in Parkinson’s disease according to its severity and duration
Main finding · Any fractureResult — go to the resultAdjusted hazard ratio 1.49 95% CI 1.44–1.56Authors' conclusion
The prevalence of PD was related to an increased risk of fractures in this nationwide study, and PD severity was linearly associated with fracture risk.
Study context
- Population
- Patients with prevalent Parkinson's disease (PD) and a comparison cohort, Korean National Health Insurance Service database
- Participants
- 10,333 vs 6,501,464
- Exposure
- Prevalent Parkinson's disease vs comparison cohort
- PDn = 10,333
- Comparisonn = 6,501,464reference
- Outcome
- Fracture risk according to the prevalence, severity, and duration of PD
Methodological detailspopulation-based, nationwide, Cox proportional hazard methods
- Population-based
- Nationwide
- Cox proportional hazard methods
Main finding
Any fracture
Adjusted hazard ratio
1.49
95% CI 1.44–1.56
PDvs Comparison
aHR 1.49 (95% CI 1.44–1.56)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Hip fracture (largest risk increase among sites) | 2.16 (1.95–2.38) | |
| Any fracture by PD severity (severe disease)Severe PDvs controls | 1.65 (1.53–1.79) | |
| 0.512Adjusted hazard ratio (log scale) |
Any fracture by PD severity (severe disease)
- Risk of any fracture increased linearly with PD severity; highest in severe disease
Fracture risk by PD duration
- No significant association between PD duration and fracture risk
Original publication
Fracture risk in Parkinson’s disease according to its severity and duration. Osteoporos Int. Published 7 October 2022. doi:10.
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