Focus on Liver Function Abnormalities in Patients With Turner Syndrome: Risk Factors and Evaluation of Fibrosis Risk
Authors' conclusion
Patients with TS have a high prevalence of LFA. However, 10% are at high risk of developing fibrosis. The FIB-4 score is useful and should be part of the routine screening strategy. Longitudinal studies and better interactions with hepatologists should improve our knowledge of liver disease in patients with TS.
Study context
- Population
- Adult patients with Turner syndrome (TS) evaluated during a day hospital visit; mean age 31.15 ± 11.48 years
- Participants
- 264 patients
- Outcome
- Liver enzymes (ALT, AST, GGT, ALP), FIB-4 score, liver US, elastography and liver biopsies when available
Methodological detailsmonocentric, retrospective
- Monocentric
- Retrospective
Main finding
As reported in the abstract
Overall prevalence of liver function abnormalities (LFAs)
42.8%
Mean FIB-4 score, entire cohort
0.67 ± 0.41
Patients at risk of developing fibrosis
Less than 10%
Cirrhosis on liver biopsy
2 of 19
Observational data: associations, not effects.
Further findings
LFA prevalence: premenopausal patients with natural cycles vs those receiving hormone replacement therapy
- No significant difference in LFA prevalence
- P = 0.063
Hormone replacement therapy and abnormal GGT levels
- No statistically significant correlation (multivariate analysis adjusted for age)
- P = 0.12
Original publication
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