Femur geometry influences atypical femoral fracture location
Authors' conclusion
Our three-dimensional analysis of whole femur geometry indicates that lateral bowing influences fracture location and may play a role in AFF pathophysiology.
Study context
- Population
- Patients with atypical femoral fracture (AFF) with CT scans
- Participants
- 57 patients
- Exposure
- Subtrochanteric vs midshaft AFF
- Outcome
- Association of whole-femur geometry variations (principal component scores, discrete measures) with AFF location
Methodological detailsstatistical shape modeling, three-dimensional CT analysis
- Statistical shape modeling
- Three-dimensional CT analysis
Main finding
As reported in the abstract
- Two principal component scores (lateral bowing and anteversion) distinguished between fracture location
- p ≤ 0.005
- PC 1 (greater lateral bowing, less anteversion) correlation with more distal fracture location
- r = 0.41, p = 0.001
- PC 3 (greater lateral bowing, less anteversion) correlation with more distal fracture location
- r = 0.48, p < 0.001
Observational data: associations, not effects.
Original publication
Femur geometry influences atypical femoral fracture location. Osteoporos Int. Published 8 August 2025. doi:10.
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