Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study
Main finding · Female sex in incident painful vs painless DPNResult — go to the resultOdds ratio 2.69 95% CI 1.41–6.23Authors' conclusion
In this first prospective study to investigate the risk factors for painful DPN, we definitively demonstrate that female sex is a risk factor for painful DPN. Additionally, there is less evidence of diabetic nephropathy in incident painful, compared with painless, DPN. Thus, painful DPN is not driven by cardiometabolic factors traditionally associated with microvascular disease. Sex differences may therefore play an important role in the pathophysiology of neuropathic pain in diabetes. Future studies need to look at psychosocial, genetic and other factors in the development of painful DPN.
Study context
- Population
- Participants with T1D in the EURODIAB Prospective Complications Study, followed up for 7.3±0.6 (mean ± SD) years
- Participants
- 3,250 participants
- Exposure
- Incident painful diabetic peripheral neuropathy (DPN) vs painless DPN
- Painful DPNn = 41
- Outcome
- Incidence and risk factors of painful DPN
- Follow-up
- 7.3±0.6 (mean ± SD) years
Methodological detailsanalysis of the EURODIAB Prospective Complications Study
- Analysis of the EURODIAB Prospective Complications Study
Main finding
Female sex in incident painful vs painless DPN · follow-up
Odds ratio
2.69
95% CI 1.41–6.23
P = 0.004
By group
As reported in the abstract
- Incident DPN at follow-up
- 276 (23.5%) of 1172
- Incident painful DPN among incident DPN
- 41 (14.9%)
Observational data: associations, not effects.
Further findings
Macro- or microalbuminuria · follow-up · lower with painful DPN
P = 0.02
| Outcome | P value |
|---|---|
| Macro- or microalbuminuria · follow-upAdjusted for HbA1c, diabetes duration and sex | P = 0.03 |
Painful DPN among participants with DPN · baseline
- Painful DPN at baseline
- 234 (25.2%) out of 927
Original publication
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