Feasibility and Preliminary Safety of Smartphone-Based Automated Insulin Delivery in Adolescents and Children With Type 1 Diabetes
Authors' conclusion
The smartphone-based AID was feasible and safe in sequentially younger cohorts of adolescents and children.
Study context
- Population
- Pediatric participants with T1D in three age cohorts: adolescents (12-<18 years, n = 8), school-age (8-<12 years, n = 7), young children (2-<8 years, n = 5)8F
- Participants
- 20 participants
- Comparison
- Smartphone-based automated insulin delivery (AID) vs preceding sensor augmented pump (SAP) therapy
- Outcome
- Primary outcomes and stopping criteria defined using fingerstick BG data
- Follow-up
- 48 hours
Methodological detailsthree sequential age-based cohorts, 48-hour, unannounced exercise, unrestricted meals
- Three sequential age-based cohorts
- 48-hour
- Unannounced exercise
- Unrestricted meals
Main finding
As reported in the abstract
Fingerstick BG primary outcomes during AID
- No more than one blood glucose (BG) <50 mg/dL except in one young child participant
- No instance of more than two episodes of BG ≥300 mg/dL lasting longer than 2 hours
Secondary outcomes
CGM TIR 70 to 180 mg/dL · statistically similar
P = 0.145
Overnight glucose CV
P < 0.001
Overnight glucose SD
P = 0.009
System use during AID
- Time in closed-loop mode
- 92.7%
- Time connected to the continuous glucose monitoring (CGM)
- 99.6%
- Participants and parents/guardians satisfied with the system
Safety
- Adverse events — AID
- 0 events
Original publication
Feasibility and Preliminary Safety of Smartphone-Based Automated Insulin Delivery in Adolescents and Children With Type 1 Diabetes. J Diabetes Sci Technol. Published 16 August 2022. doi:10.
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