Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery
Authors' conclusion
These findings collectively suggest that changes in gene expression within gustatory papillae contribute to fat taste sensitivity after sleeve gastrectomy.
Study context
- Population
- Women with severe obesity undergoing sleeve gastrectomy
- Exposure
- Lipid-unimproved vs lipid-improved patients after SG
- Outcome
- Fat taste sensitivity and fungiform papillae gene expression
- Follow-up
- 6 months after SG
Methodological detailstranscriptomic profiling of fungiform papillae, before and 6 months after sleeve gastrectomy
- Transcriptomic profiling of fungiform papillae
- Before and 6 months after sleeve gastrectomy
Main finding
As reported in the abstract
6 months after SG
- Lipid-improved and -unimproved subgroups had similar initial anthropometric parameters
- Lipid-unimproved: lower weight loss and higher fasting plasma insulin, C-reactive protein and fibrinogen
- Lipid-unimproved: overexpression of inflammation and apoptosis genes, some positively correlated with high lipid detection thresholds (low sensitivity); TRPM5 down-expressed
- Lipid-improved: upregulated genes of cell renewal, neuronal function and receptor recycling, associated with better lipid detection
- Pathway enrichment: immune activities in lipid-unimproved, anti-inflammatory activities in lipid-improved
Observational data: associations, not effects.
Original publication
Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery. Obesity (Silver Spring). Published 22 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →