Factors Associated with Survival in Anaplastic Thyroid Carcinoma: A Multicenter Study from the ENDOCAN-TUTHYREF Network
An erratum to this article was published (Thyroid, Jan 2024 ↗)
Authors' conclusion
Factors independently associated with improved OS in ATC included: European Cooperative Oncology Group performance status, disease stage, multimodality treatment, synchronously transformed ATC, and lower NLR. Long-term OS was observed in selected patients with ATC who underwent multimodal treatment.
Study context
- Population
- Patients with anaplastic thyroid carcinoma (ATC) diagnosed 2010–2020, national database of the French ENDOCAN-TUTHYREF network; 61% female, median age 72 years (IQR 62–80)
- Participants
- 360 patients
- Exposure
- Factors associated with overall survival (OS) in ATC
- Outcome
- Overall survival (OS)
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
Factors associated with OS (multivariable analysis, stage IVb-IVc patients)
- ECOG performance status 0-1: higher OS, HR
- 0.6 (0.4-0.9), p < 0.02 (CI)
- Stage IVb: higher OS, HR
- 0.5 (0.4-0.8), p < 0.001 (CI)
- Multimodal treatment (surgery and chemoradiotherapy): higher OS, HR
- 0.07 (0.04-0.1), p < 0.001 (CI)
- p-ATC (vs st-ATC): worse OS, HR
- 1.83 (1.33-2.51), p = 0.001 (CI)
- Neutrophil-to-lymphocyte ratio (NLR) >5.05: worse OS, HR
- 2.05 (1.39-3.05), p < 0.001 (CI)
Observational data: associations, not effects.
Further findings
Median OS
- Overall, months
- 6.8 (5.5-8.1) (CI)
- Stage IVa
- not reached
- Stage IVb, months
- 11.4 [8.2-17.8]
- Stage IVc, months
- 4.6 [3.5-5.7]
ATC type
- Pure ATC (p-ATC)
- 62.5%
- Mixed (synchronously-transformed) ATC (st-ATC)
- 26.7%
Treatments administered
- Surgery
- 69 (19.2%)
- Radiation therapy to the neck
- 214 (59.4%)
- Chemotherapy
- 254 (70.6%)
- Best supportive care
- 66 (18.3%)
Original publication
Factors Associated with Survival in Anaplastic Thyroid Carcinoma: A Multicenter Study from the ENDOCAN-TUTHYREF Network. Thyroid. Published 13 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →