Factors Associated With Nocturnal Hypoglycemia After Exercise in the Type 1 Diabetes and Exercise Initiative (T1DEXI)
Authors' conclusion
In the T1DEXI study, exercise was associated with increased nocturnal hypoglycemia risk in adults with type 1 diabetes.
Study context
- Population
- Adults with T1D in the T1DEXI study12,340 nights
- Participants
- 496 adults
- Exposure
- Exercise days vs sedentary days
- Outcome
- Nocturnal hypoglycaemia: CGM 54-69 mg/dL (level 1) or <54 mg/dL (level 2) for ≥15 min between midnight and 6:00 a.m.
Methodological detailsreal-world
- Real-world
Main finding
As reported in the abstract
Level 1 nocturnal hypoglycaemia
P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Level 1 nocturnal hypoglycaemia by TBR in 24 h preceding exerciseTBR ≥4% vs TBR <4% | TBR ≥4% 22.9% · TBR <4% 11.7% | P < 0.001 |
| Level 2 nocturnal hypoglycaemia by TBR in 24 h preceding exerciseTBR ≥4% vs TBR <4% | TBR ≥4% 10.2% · TBR <4% 3.3% | P < 0.001 |
| Level 1 nocturnal hypoglycaemia by insulin deliveryHCL vs Standard pumps or MDI | HCL 9.7% · Standard pumps 20.3% · MDI 17.3% | P < 0.001 |
| Level 2 nocturnal hypoglycaemia by insulin deliveryHCL vs Standard pumps or MDI | HCL 3.2% · Standard pumps 7.2% · MDI 5.8% | P < 0.001 |
Factors associated with reduced risk
- Lower preexercise TBR, higher preexercise and bedtime glucose, no hypoglycaemia during or within 4 h after exercise, and HCL delivery were associated with reduced risk
Original publication
Factors Associated With Nocturnal Hypoglycemia After Exercise in the Type 1 Diabetes and Exercise Initiative (T1DEXI). Diabetes Care. Published 5 June 2026. doi:10.
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