Diabetes complications

Extracorporeal shock wave therapy (extracorporeal shockwave therapy (ESWT)) favors healing of diabetic foot ulcers: A systematic review and meta-analysis

Diabetes Res Clin PractPublished Systematic review and meta-analysis of randomised trials

Pooled result · Complete healed ulcersResult — go to the resultRelative risk 1.57 95 % CI 1.26–1.95

Authors' conclusion

ESWT has shown promising efficacy and a favorable safety profile in the treatment of DFUs.

Study context

Population
Patients with diabetic foot ulcers (DFUs); Randomized controlled trials (RCTs) published before August 8, 202310 RCTs
Comparison
ESWT vs controls
Outcome
Complete healed ulcers

Pooled result

As reported in the abstract

Relative risk

1.57

95 % CI 1.26–1.95

ESWTvs Controls
RR 1.57 (95 % CI 1.26–1.95)

Further pooled results

OutcomeRR (95 % CI)
Unchanged ulcers0.25 (0.14–0.42)
OutcomeMD (95 % CI)P value
Average TcPO21.71 (1.22–2.19)P < 0.001

Subgroups by control: Hyperbaric oxygen therapy (HOT) and standard of care (SOC)

ESWT was better than both HOT and SOC

≥ 50 % improved ulcers

Not significantly different between ESWT and controls

Safety

Treatment-emergent adverse events (TEAEs) not significantly different between ESWT and controls

Original publication

Extracorporeal shock wave therapy (ESWT) favors healing of diabetic foot ulcers: A systematic review and meta-analysis. Diabetes Res Clin Pract. Published 3 September 2024. doi:10.1016/j.diabres.2024.111843

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