Exploring the mediating role of triglyceride-glucose (TyG)-related indicators in the relationship between biological aging and late-stage cardiovascular-kidney-metabolic in middle-aged and older adults
Authors' conclusion
Biological aging is closely related to the risk of late-stage CKM, with TyG metrics playing a partial mediating role. The cross-sectional association identified in our study, while noteworthy, precludes causal inference and therefore warrants future research to explore if modulating biological aging holds clinical significance for CKM syndrome.
Study context
- Population
- U.S. adults aged ≥45 years, NHANES (1999–2018)
- Participants
- 3,710 adults
- Exposure
- Biological aging and TyG-related indicators vs late-stage cardiovascular-Kidney-Metabolic (CKM)
- Outcome
- Late-stage CKM (stages 3-4)
Methodological detailsweighted multivariate regression, mediation analysis
- Weighted multivariate regression
- Mediation analysis
Main finding
As reported in the abstract
Late-stage CKM
OR per 1-year increase in KDM biological age
1.02
95 % CI: 1.01–1.03
OR per 1-unit higher TyG
1.45
95 % CI: 1.20–1.76
Observational data: associations, not effects.
Original publication
Exploring the mediating role of TyG-related indicators in the relationship between biological aging and late-stage cardiovascular-kidney-metabolic in middle-aged and older adults. Diabetes Res Clin Pract. Published 7 November 2025. doi:10.
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