Exploring genetic risk factors for β-cell deterioration in type 2 diabetes mellitus: Insights from longitudinal C-peptide analysis
Authors' conclusion
Using IAD calculated by fasting serum C-peptide over 10 years, KCNJ11 (rs5219) was identified as a genetic factor that was associated with the decline in insulin secretion in Japanese patients with type 2 diabetes mellitus.
Study context
- Population
- Japanese patients with T2D without significant obesity or renal dysfunction; fasting serum C-peptide observed over 10.5 ± 4.7 years
- Participants
- 116 patients
- Exposure
- KCNJ11 homozygous susceptibility allele TT vs TC/CC
- TTn = 20
- TC/CCn = 96reference
- Outcome
- Individual annual decline of fasting serum C-peptide (IAD), by regression analysis, in patients with or without susceptible allele of candidate SNPs (KCNQ1, TCF7L2, CDKN2A/B, CDKAL1, UBE2E2, HHEX, KCNJ11)
- Follow-up
- 10.5 ± 4.7 years
Methodological detailscandidate SNP analysis
- Candidate SNP analysis
Main finding
As reported in the abstract
IAD by KCNJ11 (rs5219) genotype
TT
−2.583
range −3.285: −0.893 · × 10-2 nmol/L/year
TC/CC
−1.367
range −2.273: −0.767 · × 10-2 nmol/L/year
P = 0.035
Observational data: associations, not effects.
Further findings
- IAD (all patients)
- −1.513 [−2.635: −0.129] × 10-2 nmol/L/year
Original publication
Exploring genetic risk factors for β-cell deterioration in type 2 diabetes mellitus: Insights from longitudinal C-peptide analysis. Diabetes Res Clin Pract. Published 17 February 2025. doi:10.
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