Exploring causal effects of gut microbiota and metabolites on body fat percentage using two‐sample Mendelian randomization
Authors' conclusion
Multiple gut microbiota and metabolites were strongly associated with an increased BFP. Further studies are required to elucidate the mechanisms underlying this putative causality. In addition, BFP, a key indicator of obesity, suggests that obesity-related interventions can be developed from gut microbiota and metabolite perspectives.
Study context
- Population
- Individuals of European descent; GWAS summary data from the MiBioGen consortium and the UK Biobank
- Outcome
- Causal association of gut microbiota and blood metabolites with body fat percentage (BFP), estimated by inverse variance-weighted model
Methodological detailsinverse variance-weighted model as primary method, sensitivity analyses: pleiotropy, MR-Egger regression, heterogeneity and leave-one-out tests, validation dataset
- Inverse variance-weighted model as primary method
- Sensitivity analyses: pleiotropy, MR-Egger regression, heterogeneity and leave-one-out tests
- Validation dataset
Performance
As reported in the abstract
BFP
- o_Bifidobacteriales, negatively associated with body fat percentage (BFP): β (95% CI); False discovery rate (FDR)
- −0.05 (−0.07 to −0.03); FDR = 2.76 × 10-3
- f_Bifidobacteriaceae, negatively associated with BFP: β (95% CI); FDR
- −0.05 (−0.07 to −0.07); FDR = 2.76 × 10-3
- p_Actinobacteria, negatively associated with BFP: β (95% CI); FDR
- −0.06 (−0.09 to −0.03); FDR = 6.36 × 10-3
- c_Actinobacteria, negatively associated with BFP: β (95% CI); FDR
- −0.05 (−0.08 to −0.02); FDR = 1.06 × 10-2
- g_Bifidobacterium, negatively associated with BFP: β (95% CI); FDR
- −0.05 (−0.07 to −0.02); FDR = 1.85 × 10-2
- g_Ruminiclostridium9, negatively associated with BFP: β (95% CI); FDR
- −0.03 (−0.06 to −0.01); FDR = 4.81 × 10-2
- G_Olsenella, positively associated with BFP: β (95% CI); FDR
- 0.02 (0.01-0.03); FDR = 2.16 × 10-2
- Valine (only metabolite associated with BFP): β (95% CI); FDR
- 0.77 (0.5-1.04); FDR = 8.65 × 10-6
Further findings
Validation dataset
- f_Bifidobacteriales, o_Bifidobacteriales, c_Actinobacteria and p_Actinobacteria significantly associated with BFP in the validated dataset
Original publication
Exploring causal effects of gut microbiota and metabolites on body fat percentage using two‐sample Mendelian randomization. Diabetes Obes Metab. Published 3 June 2024. doi:10.
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