Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Continuous Subcutaneous Insulin Infusion Therapy: A Systematic Review and Meta-analysis
Authors' conclusion
This systematic review demonstrated that studies on the risk factors and clinical consequences of lipohypertrophy in CSII users are limited and that the currently published data are insufficient to draw definitive conclusions.
Study context
- Population
- People with diabetes using CSII (insulin pumps); studies in English from 1990 to March 19, 2024 (MEDLINE/PubMed, Embase, CENTRAL)9 studies
- Outcome
- Risk factors and clinical consequences of lipohypertrophy in CSII users
Pooled result
As reported in the abstract
Prevalence of lipohypertrophy in CSII users (meta-analyses of two factors)
Estimate (95% CI)
Individuals incorrectly rotatingimproper cannula site rotation
prevalence odds ratio, pOR 2.59(1.39–4.83)
Gendermale sex; gender had no impact on the prevalence of lipohypertrophy
pOR 1.13(0.62–2.06)
Further pooled results
Clinical consequences of lipohypertrophy
- Not possible to draw conclusions about clinical consequences due to limited data
Original publication
Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Continuous Subcutaneous Insulin Infusion Therapy: A Systematic Review and Meta-analysis. J Diabetes Sci Technol. Published 22 March 2025. doi:10.
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