Continuous Glucose Monitoring Improves Detection of Glycemic Excursions in Hemodialysis Patients With Type 2 Diabetes
Authors' conclusion
In participants with T2D and ESKD on hemodialysis, CGM improved the detection of hyperglycemic and hypoglycemic events, particularly nocturnal and prolonged episodes. CGM revealed distinct glycemic patterns related to dialysis sessions, potentially enabling more personalized management.
Study context
- Population
- Insulin-treated adults with T2D and end-stage kidney disease on hemodialysis for ≥90 days; age 57.7 ± 9 years, HbA1c 7.09%each assessed by both methods
- Participants
- 59 adults
- Exposure
- Continuous glucose monitoring (CGM) vs capillary blood glucose testing
- Outcome
- Detection of glycemic excursions with CGM vs CBG
Main finding
As reported in the abstract
| Group | Value | Time-in-range (TIR) |
|---|---|---|
| CBG | mean 165.7 ± 41.8 | 68% ± 23 |
| CGM | mean 188.9 ± 45.0 | 51% ± 26 |
Value
CBGmean 165.7 ± 41.8
CGMmean 188.9 ± 45.0
Time-in-range (TIR)
CBG68% ± 23
CGM51% ± 26
- CGM vs CBG: P < 0.001
Observational data: associations, not effects.
Further findings
Hypoglycemia <70 mg/dL detected
P = 0.005
Hypoglycemia <54 mg/dL detected
P = 0.08
Hyperglycemia detected by CGM
- Participants with hyperglycemic episodes of 180 mg/dL
- all
- Time above range (TAR) 180 mg/dL
- 47.8% ± 27
- Participants with episodes >250 mg/dL
- 90%
- TAR >250 mg/dL
- 20.9% ± 21.7
Nocturnal and prolonged hypoglycemia <70 mg/dL
- Nocturnal hypoglycemia, detected only by CGM
- 29%
- Prolonged hypoglycemia, detected only by CGM
- 12%
CGM patterns related to dialysis
- Improved glucose on predialysis days, lower glucose during hemodialysis, rapid rise postdialysis
Original publication
Continuous Glucose Monitoring Improves Detection of Glycemic Excursions in Hemodialysis Patients With Type 2 Diabetes. J Clin Endocrinol Metab. Published 22 March 2025. doi:10.
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