Exercise-induced increase in muscle insulin sensitivity in men is amplified when assessed using a meal test
Authors' conclusion
Hyperglycaemia after meal ingestion results in larger differences in muscle glucose uptake between rested and exercised muscle than previously observed during EHCs. These findings indicate that the ability of exercise to increase insulin-stimulated muscle glucose uptake is even greater when evaluated with a meal test than has previously been shown with EHCs.
Study context
- Population
- Recreationally active men
- Participants
- 10 men
- Comparison
- Exercised leg vs rested leg during a meal test; compared with previous euglycaemic-hyperinsulinaemic clamp (EHC) studies
- Outcome
- Leg glucose uptake and glucose clearance after meal test
- Follow-up
- 3 h after meal test start (4 h post-exercise)
Methodological detailsone-legged knee extensor exercise model, comparison with historical EHC data, Historical comparison: n=106 participants from 13 EHC studies
- One-legged knee extensor exercise model
- Comparison with historical EHC data
- Historical comparison: n=106 participants from 13 EHC studies
Main finding
As reported in the abstract
3 h after meal test start (4 h post-exercise)
Muscle interstitial glucose lower in exercised vs rested leg
16%
Plasma glucose and insulin peaked after meal test initiation
45 min
Original publication
Exercise-induced increase in muscle insulin sensitivity in men is amplified when assessed using a meal test. Diabetologia. Published 25 April 2024. doi:10.
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