Examining the Influence of the Route of Administration and Dose of Estradiol on Serum Estradiol and Testosterone Levels in Feminizing Gender-Affirming Hormone Therapy
Authors' conclusion
Oral estradiol can be titrated to achieve a stepwise decrease in serum T. The intramuscular ROA appears to be the most potent delivery of estradiol with impact on serum hormone levels with doses on the low end of guideline-suggested ranges. Serum leutenizing hormone and follicle stimulating hormone may also help with the management of feminizing GAHT.
Study context
- Population
- Transfeminine individuals with an active prescription for estradiol for feminizing gender-affirming hormone therapy and serum hormone levels available
- Participants
- 573 individuals
- Exposure
- Routes of administration and doses of estradiol
- Outcome
- Effect of estradiol dose and route on serum E2 and testosterone
Methodological detailsMultiple linear regression and analysis of variance
- Multiple linear regression and analysis of variance
Main finding
As reported in the abstract
Oral estradiol: only route with linear dose-response; reduction in T per 1 mg/d increase
19.03 ng/dL
P = .005
Observational data: associations, not effects.
Further findings
- Higher oral estradiol doses associated with lower mean serum LH and FSH
- P < 0.05
Original publication
Examining the Influence of the Route of Administration and Dose of Estradiol on Serum Estradiol and Testosterone Levels in Feminizing Gender-Affirming Hormone Therapy. Endocr Pract. Published 12 October 2024. doi:10.
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