Examining the roles of body composition, energy expenditure and substrate metabolism in the control of daily energy intake in adolescents with obesity
Authors' conclusion
The present study provides the first evidence regarding the role of RMR as a main tonic signal of appetite control mediating the effect of body composition and mainly FFM (over FM) on daily EI in adolescents with obesity. It also suggests for the first-time relationships between 24-h CHO and protein oxidation and daily EI in this population.
Study context
- Population
- Adolescents with severe obesity (14.1 ± 1.5 years; 14 girls); mean body weight 92.2 ± 17.2 kg, BMI 33.98 ± 4.14 kg.m-2
- Participants
- 26 adolescents
- Outcome
- Ad libitum 24-h energy intake and its relation to body composition, EE and substrate metabolism
Methodological detailsmetabolic chamber 36-h stay, path analysis
- Metabolic chamber 36-h stay
- Path analysis
Main finding
As reported in the abstract
- 24-h energy intake (EI) vs body weight
- rho = 0.597, p = 0.014
- 24-h EI vs Fat Free Mass (FFM) (kg)
- rho = 0.576, p = 0.019
- 24-h EI vs 24-h total energy expenditure (EE)
- rho =0.675, p < 0.001
- 24-h EI vs Resting Metabolic Rate (RMR)
- rho =0.632, p = 0.005
- 24-h EI vs 24-h CHO oxidation rates
- rho = 0.716, p < 0.001
- 24-h EI vs urinary nitrogen excretion
- rho =0.28, p < 0.001
- Direct effect of FFM (kg) on RMR
- 0.87 (p < 0.001)
- Direct effect of Fat Mass (FM) (kg) on RMR
- 0.027 (p = 0.74)
- Effect of FFM on 24-h EI mediated by RMR
- 96%
- Effect of FM on 24-h EI mediated by RMR
- 67%
Original publication
Examining the roles of body composition, energy expenditure and substrate metabolism in the control of daily energy intake in adolescents with obesity. Int J Obes (Lond). Published 13 March 2025. doi:10.
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