Evolving our understanding of vitamin D, periostin levels and cardiovascular risk in the elderly: a cross sectional study
Authors' conclusion
This analysis identified a significant association between periostin and serum vitamin D levels, both linked to increased CV risk in the elderly, suggesting their potential role in CV disease.
Study context
- Population
- Elderly people from the InCHIANTI Biobank, Italy; aged 72.8 ± 15.7 years
- Participants
- 299 people
- Exposure
- Low vs high periostin
- Outcome
- CV risk score (arbitrary) by periostin level
Methodological detailssubgroup of InCHIANTI Biobank
- Subgroup of InCHIANTI Biobank
Main finding
As reported in the abstract
Low periostin (< 150 pmol/L)
2.9
± 1.4
High periostin
2.2
± 1.4
P < 0.0001
- Multivariate model: only low dihydroxyvitamin D (< 41 pg/mL) remained significantly associated with high cardiovascular (CV) risk
- OR: 3.0-3.45, p < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | High periostin | P value |
|---|---|---|
| SCORE2/SCORE2-OP 10-year CV risk by periostin levelLow periostin (< 150 pmol/L) vs High periostin · higher with low periostin | 14.7 ± 11.7 | P < 0.0001 |
- SCORE2/SCORE2-OP 10-year CV risk by periostin level: Low periostin (< 150 pmol/L) 21.1 ± 12.5 %
Correlation of periostin with vitamin D metabolites
- Periostin vs dihydroxyvitamin D, r
- 0.39, p < 0.0001
- Periostin vs 25(OH)D, r
- 0.76, p < 0.0001
Factors associated with periostin < 150 pmol/L (logistic regression)
- 25(OH)D < 20 ng/mL, OR
- 22.4, p < 0.0001
- Age ≥ 75 years, OR
- 2.7, p = 0.006
- Dyslipidemia, OR
- 3.26, p = 0.0003
Original publication
Evolving our understanding of vitamin D, periostin levels and cardiovascular risk in the elderly: a cross sectional study. Osteoporos Int. Published 9 December 2025. doi:10.
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