Evaluation of bone-related mechanical properties in female patients with long-term remission of Cushing's syndrome using quantitative computed tomography–based finite element analysis
Authors' conclusion
Women with prior hypercortisolism have reduced trabecular vBMD and impaired bone geometrical and mechanical properties, which may contribute to an elevated fracture risk despite long-term remission.
Study context
- Population
- Women with Cushing's syndrome (CS) in remission (mean age 51 ± 11; BMI 27 ± 4 kg/m²; mean time of remission 120 ± 90 months) and matched female controlsmatched controls
- Participants
- 32 vs 32
- Comparison
- Women with CS in long-term remission vs matched controls
- CSn = 32
- Controlsn = 32reference
- Outcome
- Proximal femur QCT and finite element (FE) measures
Methodological detailsage-, BMI- and gonadal status-matched controls, quantitative computed tomography (QCT)-based finite element analysis
- Age-, BMI- and gonadal status-matched controls
- QCT-based finite element analysis
Main finding
As reported in the abstract
- Trabecular volumetric bone mineral density (vBMD) at total hip and trochanter lower in CS vs controls
- P < .05
- Average cortical thickness lower, buckling ratio greater in CS vs controls
- P < .01
- All strain and stress values higher in CS vs controls
- P < .05
Observational data: associations, not effects.
Further findings
2D DXA-derived measures (Areal BMD (aBMD), trabecular bone score (TBS))
- Similar between patients and controls
- P > 0.05
Prior hypercortisolism as predictor of VM and MPS
- VM
- β .30, P = .014
- MPS
- β .30, P = .015
- Adjusted for age, BMI, menopause, delay to diagnosis, and duration of remission
Original publication
Evaluation of bone-related mechanical properties in female patients with long-term remission of Cushing's syndrome using quantitative computed tomography–based finite element analysis. Eur J Endocrinol. Published 23 January 2024. doi:10.
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