Etiologic Determinants and Characteristics of Diabetes in Haitian Youth (EDDHY Study)
Authors' conclusion
Idiopathic T1D is common among youth in Haiti. A significant proportion of all patients had preserved C-peptide secretion. Overall, predisposing and protective HLA patterns were identified.
Study context
- Population
- Haitian youth with T1D aged <22 years and diagnosed for < 2 yearsHuman leukocyte antigen (HLA): 54 subjects, 66 controls
- Participants
- 110 participants
- Exposure
- Idiopathic T1D vs Immune-mediated T1D
- Idiopathic T1Dn = 62
- Outcome
- Characteristics of youth-onset T1D
Methodological detailsHLA genotyping case-control component
- HLA genotyping case-control component
Main finding
As reported in the abstract
- Idiopathic T1D
- 62 (56.4%)
- Low fasting C-peptide (FCP) levels
- 71 (64.5%)
- DKA at diagnosis
- 18 (16.4%)
- Onset age, years
- 13.5 ± 4.2 (range 2-21)
- Disease duration, months
- 11.7 ± 8.1 (range 0-24)
- Male
- 54%
- TPOAb positive
- 1.1%
- Thyroglobulin antibodies (TG-Ab) positive
- 2.2%
Observational data: associations, not effects.
Further findings
Age at diagnosis · older with idiopathic T1D
P = 0.01
BMI z-score in idiopathic T1D by age (<14 vs ≥14 years)
- BMI z-score, aged <14 vs ≥14 years
- −0.29 ± 1.52 vs., −1.15 ± 1.18, p=0.01
HLA associations with T1D
- Risk alleles: DRB1 ∗ 03:01, DRB1 ∗ 09:01, DQB1 ∗ 02:01, DQB1 ∗ 02:02
- Protective alleles: DRB1 ∗ 08:04, DRB1 ∗ 15:03, DQB1 ∗ 06:02
- Predisposing haplotypes: DRB1 ∗ 03:01:01~DQB1 ∗ 02:01:01, DRB1 ∗ 09:01:02~DQB1 ∗ 02:02:01; protective: DRB1 ∗ 15:03:01~DQB1 ∗ 06:02:01
Original publication
Etiologic Determinants and Characteristics of Diabetes in Haitian Youth (EDDHY Study). Pediatr Diabetes. Published 25 May 2025. doi:10.
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