Ethnic differences in adipose tissue dysfunction and insulin resistance: a scoping review
Authors' conclusion
Current trends indicate intrahepatic lipid is lower in BA but greater in SA compared to WE populations, indicting possible ethnic disparities in the role ATD in the development of T2D. Few ethnicity studies have investigated multiple characteristics of ATD between BA and SA groups in a single study which may be needed to elucidate ethnic-specific pathophysiology of T2D.
Study context
- Population
- Adults (>18 years) of south Asian (SA), black (BA) or white (WE) ethnicity in studies comparing ectopic fat, with insulin sensitivity and adipokine data where present
- Participants
- 31 studies
- Comparison
- South Asian vs black vs white ethnicity
- Outcome
- Characteristics of included studies
Methodological detailsMEDLINE search
- MEDLINE search
Main finding
As reported in the abstract
- Studies conducted in USA
- 22
- Studies focused on BA
- 28
- Studies on intrahepatic lipids
- 26
- Studies on intrapancreatic lipids
- 3
- Studies on intramyocellular lipids
- 8
- Studies investigating leptin and adiponectin alongside ectopic fat by ethnicity
- 2
Original publication
Ethnic differences in adipose tissue dysfunction and insulin resistance: a scoping review. Diabetes Res Clin Pract. Published 6 August 2025. doi:10.
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