Lipids & metabolic liver disease
Endotoxin Markers Are Elevated in Adolescents With Obesity With and Without Metabolic Dysfunction‐Associated Steatotic Liver Disease
Authors' conclusion
Serum markers of endotoxin activity and inflammation are increased in adolescents with obesity but are not further increased in patients with mild to moderate MASLD.
Study context
- Population
- Adolescents with biopsy-proven MASLD and obesity, and control adolescents without MASLD with obesity or normal weight
- Participants
- 46 / 28 / 34
- Exposure
- Adolescents with obesity and MASLD vs obesity without MASLD vs normal weight
- MASLDn = 46
- Obesity (Ob)n = 28
- Normal weight (NW)n = 34reference
- Outcome
- Serum endotoxin markers (EndoCab IgG, LBP, sCD14) and CRP
Methodological detailsbiopsy-proven MASLD
- Biopsy-proven MASLD
Main finding
As reported in the abstract
Higher EndoCab IgG in MASLD and Ob vs NW
56%
Higher lipopolysaccharide binding protein (LBP) in MASLD and Ob vs NW
33%
Higher C-reactive protein (CRP) in MASLD and Ob vs NW
11-fold
Observational data: associations, not effects.
Further findings
Correlations of LBP and CRP with trunk and total body fat
- LBP correlated with trunk and total body fat
- r = 0.45, p < 0.001
- CRP correlated with trunk and total body fat
- r = 0.64, p < 0.001
- LBP correlated with CRP
- r = 0.42, p < 0.001
Endotoxin markers by sex, steatosis grade and fibrosis stage within MASLD
- No endotoxin marker varied between boys and girls, or with steatosis grade or fibrosis stage within MASLD
Original publication
Endotoxin Markers Are Elevated in Adolescents With Obesity With and Without Metabolic Dysfunction‐Associated Steatotic Liver Disease. Pediatr Obes. Published 10 February 2026. doi:10.
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