Endocrine Management and Clinical Outcomes in a Cohort of Pediatric Patients Undergoing Total Pancreatectomy with Islet Autotransplantation
Authors' conclusion
Pediatric patients at our institution have favorable endocrine outcomes as evidenced by median HbA1C under the goal of 6.5% through the initial 3 years by following our modified management protocols.
Study context
- Population
- Pediatric recipients of total pancreatectomy with islet autotransplantation (TPIAT) at one institution, managed with modified endocrine protocols
- Participants
- 86 recipients
- Outcome
- Post-TPIAT glycemic management (HbA1c)
- Follow-up
- Through 4 years postsurgery
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Median HbA1c · 12 months post-TPIAT
TPIAT
6.0
median · 25-75th percentile 5.6–6.7 · % · n = 82
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Median HbA1c · 18 months | TPIAT median 6.4 (25-75th percentile 5.6–7.5) % · n = 56 |
| Median HbA1c · 2 years | TPIAT median 6.4 (25-75th percentile 5.6–7.4) % · n = 46 |
| Median HbA1c · 3 years | TPIAT median 6.5 (25-75th percentile 5.5–8.1) % · n = 31 |
| Median HbA1c · 4 years | TPIAT median 7.2 (25-75th percentile 6.2–8.3) % · n = 16 |
Original publication
Endocrine Management and Clinical Outcomes in a Cohort of Pediatric Patients Undergoing Total Pancreatectomy with Islet Autotransplantation. Diabetes Technol Ther. Published 26 October 2023. doi:10.
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