Endocrine, cardiac and neuropsychological aspects of adult congenital adrenal hyperplasia
Authors' conclusion
A sex-specific comorbidity profile is evident in CAH, with females presenting with decreased metabolic and overall self-reported health, whereas males with CAH presented with increased cognitive complaints and autistic traits.
Study context
- Population
- Adults with congenital adrenal hyperplasia (CAH) and age- and sex-matched controls, Aarhus University Hospital
- Participants
- 37 vs 33
- Exposure
- CAH vs age- and sex-matched controls
- CAHn = 37
- Controlsn = 33reference
- Outcome
- Height
Methodological detailssingle-centre, age- and sex-matched controls
- Single-centre
- Age- and sex-matched controls
Main finding
As reported in the abstract
- CAH vs Controls: P < 0.01
Observational data: associations, not effects.
Further findings
Haemoglobin, females · higher with CAH
P = 0.003
BMI, females · higher with CAH
P = 0.006
E-wave deceleration time, females · prolonged with CAH
P = 0.015
| Outcome | CAH | Controls | P value |
|---|---|---|---|
| HOMA-IR, femalesReduced insulin sensitivity with CAH | 2.7 | 1.9 | P = 0.018 |
| E/é ratio, females | 5.4 | 4.5 | P = 0.017 |
| Autistic scores, malesHigher with CAH | 19.9 | 14.9 | P = 0.068 |
- Cognitive complaints, males · more with CAH
- P = 0.034
Self-reported quality of life (QoL), females
- Lower self-reported QoL in females with CAH vs female controls
Writing problems
- More individuals with CAH than controls reported writing problems
Original publication
Endocrine, cardiac and neuropsychological aspects of adult congenital adrenal hyperplasia. Clin Endocrinol (Oxf). Published 4 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →