Elevated Preoperative TPO Ab Titers Decrease Risk for Differentiated Thyroid Cancer (DTC) in a Linear Fashion: A Retrospective Analysis of 1635 Cases
Main finding · DTCResult — go to the resultOdds ratio 0.64 CI 0.52–0.80Authors' conclusion
Higher TPO-Ab titers appear protective against DTC in our large multicenter cohort of patients who underwent thyroidectomies. Rising preoperative TPO-Abs titers conferred linearly increasing protection against DTC.
Study context
- Population
- Individuals who underwent thyroidectomies at 4 sites (USA: 1 clinic, 2000–2013; Greece: 3 clinics, 2007–2021) with preoperative thyroid peroxidase antibodies (TPO-Abs) titers availableof 8461 surgery cases
- Participants
- 1,635 individuals
- Exposure
- TPO+ vs TPO−
- TPO+n = 540
- TPO-n = 1,095reference
- Outcome
- DTC on surgical pathology
Methodological detailsmulticentre
- Multicentre
Main finding
DTC
Odds ratio
0.64
CI 0.52–0.80
P < 0.0001
Events by group
TPO+vs TPO-
OR 0.64 (CI 0.52–0.80); P < 0.0001
As reported in the abstract
Observational data: associations, not effects.
Further findings
DTC frequency by TPO-Abs titer
- TPO-Abs <10 IU/mL
- 59.3%
- TPO-Abs <34 IU/mL
- 47.4%
- TPO-Abs 34 to 100 IU/mL
- 42.6%
- TPO-Abs 100 to 500 IU/mL
- 32.0%
- TPO-Abs >1000 IU/mL
- 19.4%
- Linear trend, P
- P less than .0001
- Rising TPO-Abs titers conferred protection against DTC in a linear fashion
Original publication
Elevated Preoperative TPO Ab Titers Decrease Risk for DTC in a Linear Fashion: A Retrospective Analysis of 1635 Cases. J Clin Endocrinol Metab. Published 14 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →