Elevated BMI impacts brain‐state dynamics within the sensorimotor‐to‐transmodal hierarchy
Authors' conclusion
The altered brain-state dynamics within the sensorimotor-to-transmodal hierarchy provide new insights into obesity-related brain dysfunctions and mental health issues.
Study context
- Population
- Participants of the Behavioral-Brain Research Project of Chinese Personality and the Human Connectome Projecttwo data sets
- Outcome
- Brain-state dynamics with increasing BMI
Methodological detailstwo independent resting-state fMRI data sets, Hidden Markov model, longitudinal sample, Behavioral-Brain Research Project of Chinese Personality, n = 1923; Human Connectome Project, n = 998
- Two independent resting-state fMRI data sets
- Hidden Markov model
- Longitudinal sample
- Behavioral-Brain Research Project of Chinese Personality, n = 1923; Human Connectome Project, n = 998
Main finding
As reported in the abstract
- Elevated BMI shifts brain activity states toward a sensorimotor metastate, making transfer to the transmodal metastate harder
- Findings reconfirmed in a longitudinal sample (n = 34) with significant BMI increase at follow-up
- Altered brain-state dynamics mediated relationships between BMI and cognitive decline and mental illness symptoms
Observational data: associations, not effects.
Original publication
Elevated BMI impacts brain‐state dynamics within the sensorimotor‐to‐transmodal hierarchy. Obesity (Silver Spring). Published 25 January 2024. doi:10.
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