Efficacy of a personalised activity plan for BREAKing UP sitting time in patients with intermittent claudication (the BREAK UP study)

Diabetes Res Clin PractPublished Before-and-after study

Authors' conclusion

An 8-week personalised activity plan to break up sitting time shows promise as a treatment for people with IC, improving walking ability and reducing time spent sitting. This study supports the use of large randomised controlled trials to further develop this treatment in people with IC.

Study context

Population
People with intermittent claudication (IC)
Outcome
Co-primary: time spent sitting and walking ability (walking impairment questionnaire)
Follow-up
8 weeks
Methodological detailssingle centre, single arm, Paired samples T-tests for normally distributed data; related-samples Wilcoxon signed rank tests for non-normally distributed data
  • Single centre
  • Single arm
  • Paired samples T-tests for normally distributed data; related-samples Wilcoxon signed rank tests for non-normally distributed data

Main finding

As reported in the abstract

Walking ability and time spent sitting (co-primary)
  • Significant improvement in both co-primary outcomes: walking ability and time spent sitting

Secondary outcomes

Significant improvement in total bouts and time in prolonged sitting, time standing and stepping, anxiety, depression, and activity levels on the vascular quality of life questionnaire

Original publication

Efficacy of a personalised activity plan for BREAKing UP sitting time in patients with intermittent claudication (the BREAK UP study). Diabetes Res Clin Pract. Published 28 September 2023. doi:10.1016/j.diabres.2023.110925

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