The efficacy of automated insulin delivery systems in children and adolescents with type 1 diabetes Mellitus: A systematic review and meta-analysis of randomized controlled trials
Authors' conclusion
According to the present meta-analysis, AID systems are superior to insulin pump therapy, sensor-augmented pumps and multiple daily insulin injections. Most of the included studies have a high risk of bias because of allocation, blinding of patients and blinding of assessment. Our sensitivity analyses showed that patients < 21 years of age with T1D can use AID systems, after proper education, following their daily activities. Further RCTs examining the effect of AID systems on nocturnal hypoglycemia, under free-living settings and studies examining the effect of dual-hormone AID systems are pending.
Study context
- Population
- Children and adolescents <21 years with T1D; Randomized controlled trials (RCTs) until August 8th, 2022
- Participants
- 915 children26 RCTs
- Comparison
- Automated insulin delivery (AID) systems vs control
- Outcome
- Main outcomes: proportion of time in target glucose range (3.9-10 mmol/L), hypoglycemia (<3.9 mmol/L) and mean HbA1C
Methodological detailsa priori subgroup and sensitivity analyses
- A priori subgroup and sensitivity analyses
Pooled result
As reported in the abstract
Main outcomes
- AID vs Control: P < 0.00001
- AID vs Control: P = 0.003
- AID vs Control: P = 0.0007
Original publication
The efficacy of automated insulin delivery systems in children and adolescents with type 1 diabetes Mellitus: A systematic review and meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. Published 23 April 2023. doi:10.
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