Effects of reducing sedentary behaviour on renal glucose uptake during insulin stimulation: A post‐hoc analysis of a 6‐month randomized controlled trial
Authors' conclusion
In patients with metabolic syndrome, insulin-stimulated renal GU increases concomitantly with a small decrease in body adiposity, independently of changes in whole-body glucose disposal.
Study context
- Population
- Patients with metabolic syndrome34 with renal data at baseline, 30 at end
- Participants
- 44 patients
- Comparison
- Guidance to reduce sedentary behaviour by 1 h/day vs maintaining usual sedentary behaviour
- Primary endpoint
- Insulin-stimulated renal glucose uptake rate (GU) by [18F]FDG-PET during hyperinsulinemic clamp
- Follow-up
- 6 months
Methodological details6-month intervention
- 6-month intervention
Primary result
As reported in the abstract
Cortical and medullary renal GU
- Cortical and medullary GU increased vs baseline, similarly in both groups
Further findings
Light and moderate-to-vigorous physical activity (PA) and BMI · study end
- PA increased and BMI slightly decreased, with no significant intervention effect
Correlates of cortical GU at baseline
- Cortical GU directly related to insulin sensitivity and inversely to BMI and circulating FFA
Correlates of change in renal GU
- Change in renal GU directly related to change in liver GU, not to change in whole-body insulin sensitivity
Original publication
Effects of reducing sedentary behaviour on renal glucose uptake during insulin stimulation: A post‐hoc analysis of a 6‐month randomized controlled trial. Diabetes Obes Metab. Published 22 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →